I found Shin Sekai Yori very interesting because it presents a compelling security dilemma: In a world where a single person can kill hundreds of thousands of innocents with a single thought, how does society respond? Psycho Pass's solution (Psycho Pass aired the same season) is a police state, where crimes are prosecuted essentially before they are even conceived by measuring a person's temperament (their potential to commit a crime). Shin Sekai Yori's solution is genetic manipulation and rigorous childhood brainwashing to suppress violent tendencies, with systematic elimination of deviants that these measures fail to control.
I find this theme fascinating because it won't be long before we as a species face a similar dilemma. Imagine a world where nuclear devices become concealable in a suitcase and fissionable material is as easy to come by as traditional explosives. A single deranged individual could wipe out an entire city and make it uninhabitable for years more. As a society, how will we deal with that threat? My bets are on the police state solution. Expect agencies like the US National Security Agency (NSA) to grow increasingly powerful as weaponry becomes increasingly advanced, to the point that even letting a single psychopath slip through could result in unacceptable economic damage and loss of human life. And at that point--who will watch the Watchers?