Kicking someone out of your room should be the easiest thing to do in life, and one of the most fulfilling. That being said if you need quiet or just want someone out of your room you can say you're gunna get some reading done or just say you want some peace and quiet. It's your room, I mean be as polite as you can be, but at the end of the day clearing people out shouldn't feel too daunting. It may be a little different when it is family. For situations like that, like when I have my girl over, I just snag a headset and let her know I am diving into a VN. She's not particularly into any of them or even most of my weeb stuff, but she respects me enough to not make a racket when I am diving into a VN or even a book. So ultimately my suggestion is to assert your DOMINANCE in your own domain and be willing to compromise at times, or @Kaguya suggestion. Cuz that plan of attack would work to; People hate getting sick.