I dunno, it depends on execution. Pick whichever want you want to make more. You're the one who's going to be spending hundreds of hours on it.
1. This is the more unique idea, though the reader (myself included) isn't prolly going to be a wrestling fan to start with, so you want some way to get the reader invested (possibly a relatable main character). Also, what type of gameplay?
2. Why is the medieval character in cyberpunk, is it that kind of world, or did they get teleported? What's the story arc? The issue with having cyberpunk setting / fantasy is that it's hard to narrow it down to a reasonable length story. This VN comes to mind: https://store.steampowered.com/app/1047010/Synergia/ If the story is more like embellishment for the game then maybe it doesn't matter so much.
Swords x Cyberpunk is pretty cool, but yeah... boils down to if the gameplay is fun, or what's the story gonna be that hooks you. What you posted isn't even a real idea... it's just a setting + saying its a simulation RPG.
As a game dev, I think if you are making a game, the game being fun is the utmost concern -- since if it's not you could have just made a non-gameplay VN with better freedom/pacing and significantly less work. (It's also possible to just have mini-games that don't take up large parts of the VN)