I did suffer from the same thing, I have a chronic disease that made me, until a few months ago, unable to leave my house alone or play on a park, so I don't have ANY friends at all, well, I had one, but that's in the past, even nowadays I still feel the loneliness grappling down my body, wasted time passing through. My life was hard, and still is, but things change and so do I, I found a passion, Cooking, I'm aiming to become a Chef, I went to a doctor to check if I could join a Gym, if that would be bad for my health, and he said it would actually be great, and so I joined it, built for me a better and healthier body, I started to learn other languages, which is something I really love, like, talking to foreign people, breaking this sort of "Language Barrier", it's great and all. So, pretty much, I found something to live for, and so i hope for you, brother.
About the heavy feeling you said, well, I feel it whenever I finish a VN, a Book or any history at all, it's a feeling of sadness but also accomplishment for completing such a great art (I don't feel it with bad VNs). However, most of the times, I feel both happiness and sadness, sadness because I wont ever be able to feel the same feeling I had when I read it for the first time, and I'll never see the characters how I once did, and happiness because I also feel growth, a person is made by thoughts and beliefs, and you will only evolve when you learn.
The moment you meet a situation that makes you uneasy or uncomfortable, that's the place you will think the most, and thinking will make you learn, so, at least for me, when I feel it, I try not to avoid it nor think of something else, I try to take the most from it, otherwise I would be just lying to myself.
As a writer (I've worked on a few games), I can confirm to you that a Writer always tries to make the person reading learn something, they'll always try to pass a tought, a belief or a way of thinking or viewing things through words, and in MY opinion, avoiding it will only dishonor the writer and all the time they took to make it, so, as a reader, I try to take/learn the most from it, and even if I don't learn anything, it'll at least makes me realize how right my own thoughts are, and thus, it itself is a way of learning.
But, even if knowing it you still want to simply get rid of this feeling, which I will not judge you for, try to play something else, watch an anime or a series or maybe even trying out a new book you've seen on a store.
Hope i could be of help.